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Studies have shown that estrogen may also help relieve some symptoms associated with mood, bone density, and heart health.* Pellets last up to three to six months depending on gender, weight, absorption rates, and the amount of deficiency or surplus of hormones present within the patient at the time of insertion

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The practical consequence is that long term safety at the doses used is genuinely unknown, and an unknown should be treated as a risk rather than as a reassurance