glutathione peroxidase hne Frontiers Form:MicroTablet

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Briefly, ferroptosis-prone PUFAs contain bis-allylic hydrogen atoms that are liable to removal from the PUFA scaffold, exposing carbon moieties that can react with ferric iron or oxygen radicals either directly, or subsequent to attachment of molecular oxygen, form lipid (hydro)peroxides

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3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimer’s disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability (Hooper et al., 2025)