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As both IBD and PD have compromised intestinal barrier functions, DJ-1 deficiency promotes cytokine-mediated inflammation (IL-1β, IL-6, TNFα, and TGFB1) and apoptosis of intestinal epithelial cells via a p53-dependent mechanism in vitro , in ex vivo colonic sacs, and in vivo (van IJzendoorn and Derkinderen, 2019
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