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This approach not only offers an alternative interpretation of the pathogenic mechanisms underlying specific targets but also expands the scope of “druggable” target screening by introducing novel biological phenotypes
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Islets isolated from WT and GCGR-KO mice were loaded with the cytoplasmic Ca 2+ indicator Fluo-4 AM, and cytoplasmic Ca 2+ concentration responses to stimulation were recorded by confocal time-lapse imaging (Fig
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