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Furthermore, pharmacological blockade of catalase or Nrf2 activity intensified ethanol intoxication in mice, and 28.2 μM /kg/day SF (a potent Nrf2 inducer) treatment for 5 days, attenuated these effects (55), leading the study’s authors to suggest that Nrf2 activation may serve as a potential therapeutic strategy for preventing acute alcoholism by regulating catalase-mediated ethanol oxidation
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