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reaction with other ROS as superoxide anion to produce peroxynitrite, which works as a signal molecule in protein modification and, finally, reaction with metals as iron of heme groups (Moreau et al., 2010
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Mechanistically, S100P orchestrates acetyl-CoA carboxylase 1 (ACC1)-dependent lipid metabolic reprogramming to promote the accumulation of polyunsaturated fatty acid (PUFA)-derived phospholipids in HCC cells, thereby enhancing the generation of lipid peroxidation byproducts
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