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Both schizophrenia and vascular dementia involve cholinergic dysfunction contributing to cognitive impairment, but schizophrenia is mainly associated with Ξ±7 nicotinic acetylcholine receptor (nAChR) abnormalities in frontalβcingulate regions, whereas VaD predominantly affects Ξ±4Ξ²2 nAChRs in hippocampal and subcortical structures (179)
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While animal studies are promising, more human research is needed before it can be recommended for clinical use
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