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Funding Statement The following agencies founded the present work: Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM) for the funding, CT&I Priority Areas Call FAPEAM 010/2021 for MAS and HHFK, and HHFK’s research under the Universal Call FAPEAM-006/2019

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Moreover, there is agreement that metabolic biomarkers such as methylmalonic acid and homocysteine can be useful in guiding the diagnosis of vitamin B12 deficiency and optimizing and monitoring treatment with vitamin B12 (Table 1)