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These enterocytes have a unique receptor complex on their apical surface, known as Cubam, which consists of two proteins: Cubilin (encoded by CUBN ) and Amnionless (encoded by AMN ).8 The Cubam receptor complex binds to the IF-Cbl complex, triggering its endocytosis which allows the enterocytes to internalize the Cbl, effectively and their deficiencies lead to Imerslund-Gräsbeck syndrome (IGS).9,10 The next phase involves the transport of Cbl from the enterocytes into the circulatory system for distribution where it is primarily transported by a protein called Transcobalamin II (TC II)

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