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Simultaneously, NNMT downregulates Hpgd , the gene encoding 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the enzyme responsible for PGE 2 degradation, causing PGE 2 accumulation and establishing a pro-inflammatory milieu [43]
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These models only partially reproduce the complexity of human AP, in which biliary, alcoholic, metabolic, and drug-related triggers coexist with comorbidities such as obesity, diabetes, and chronic alcohol use
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