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The FADD protein dimerizes with pro-caspase-8, leading to the formation of the Death-Inducing Signaling Complex (DISC), which activates pro-caspase-8, and this could either initiate apoptosis directly or activate the intrinsic apoptotic pathway to promote DNA fragmentation and cell death depending on the cell type [46]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 115.Li Z., Mao Y., Liang L., Wu S., Yuan J., Mo K., Cai W., Mao Q., Cao J., Bekker A., et al
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