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These investigations remain limited to mechanistic and molecular analysis , without drawing conclusions related to clinical outcomes

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This regulatory level may possibly be so profound that the question has been raised if the pathobiological circuits of ME/CFS may really be disease processes at all or if they may be physiological pathways that are normally activated only for short periods of time and under unusual circumstances (like fighting a disease or other threats) and that for some reason have become “hijacked” to remain perpetually activated (Kashi et al., 2019)