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Interestingly, ß-hairpin structures connecting D2 and D3 also occur in other helicases, e.g., in closely related BVDV or Orthoflavivirus NS3
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152,153 The enzyme responsible for this transformation is the SAM-dependent methyltransferase Ecm18 (Qui8) 154–156 or Swb8 in the case of the related compound SW-163D (77) and its derivatives
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