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31 The catalytic activity level of SIRT protein family members is thought to be their second most significant difference

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Our recent study, on acetaminophen-induced toxicity in macrophages has also suggested that differential inhibition of mitochondrial respiratory enzymes is associated with altered ROS/NO homeostasis in mitochondria [53].Our recent publications have also discussed extensively the mitochondrial respiratory dysfunctions under increased oxidative stress conditions [23], [25], [38], [42], [43]