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The reduction in ubiquitin levels may also be associated with involvement of ubiquitin in multiple functions and substrates in an organism outside of the proteasome system such as receptor internalization and modifications to chromatin structure (Noor et al., 2011)
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Urolithin A alleviates colitis in mice by improving gut microbiota dysbiosis, modulating microbial tryptophan metabolism, and triggering AhR activation
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