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While there was no placebo group, high doses of hydroxycobalamin alone led to a 30.5-point (60%) drop in pain scores as assessed on a visual analog scale and a 35.2-point (69%) decrease when combined with the supplemented nucleotides (38)

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this has led to the belief that humans are also capable of doing so simply because they are mammals, and although there is synthesis in some areas, it is not reabsorbable as it is located far from the ileum