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12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)

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doi: 10.1038/s41591-024-02964-1 190 HagenMBucciLBoltzSNothlingDMRotheTAnoshkinKet al